COMPARTMENTS

Subcellular localization database

SLC25A11 localizations

SLC25A11 [ENSP00000225665]

Mitochondrial 2-oxoglutarate/malate carrier protein; Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism. Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae . Involved in the regulation of apoptosis (By similarity). Acts as a tumor-suppressor gene implicated in the predisposition to metastatic paraganglioma. ; Belongs to the mitochondrial carrier (TC 2.A.29) family.

Synonyms:  SLC25A11,  I3L1P8,  Q02978,  Q6IBH0,  I3L1P8p ...

Linkouts:  STRING  Pharos  UniProt  OMIM

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence