COMPARTMENTS

Subcellular localization database

RANGRF localizations

RANGRF [ENSP00000226105]

Ran guanine nucleotide release factor; May regulate the intracellular trafficking of RAN . Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 . Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics . Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:23420830, PubMed:21621375). ECO:0000269|PubMed:18184654, ECO:0000269|PubMed:21621375,; Belongs to the MOG1 family.

Synonyms:  RANGRF,  Q9HD47,  Q9HD47p,  hQ9HD47,  29098 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence