SGSM2 localizations
SGSM2 [ENSP00000268989]
Small G protein signaling modulator 2; Possesses GTPase activator activity towards RAB32, RAB33B and RAB38 . Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation . ; Belongs to the RUTBC family.
Synonyms: SGSM2, SGSM2p, hSGSM2, B9A6J3, I3L1Y7 ...