MARCHF6 localizations
MARCHF6 [ENSP00000274140]
E3 ubiquitin-protein ligase MARCHF6; E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation . Promotes ubiquitination of DIO2, leading to its degradation . Promotes ubiquitination of SQLE, leading to its degradation . E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1 .
Synonyms: MARCHF6, MARCHF6p, hMARCHF6, A0A0B4J206, D6RHY7 ...