COMPARTMENTS

Subcellular localization database

MFHAS1 localizations

MFHAS1 [ENSP00000276282]

Malignant fibrous histiocytoma-amplified sequence 1; Probable GTP-binding protein . Functions in innate immunity and more specifically the inflammatory response as a regulator of the Toll-like receptor TLR2 and TLR4 signaling pathways . Negatively regulates the part of the TLR4 signaling pathway that leads to the activation of the transcription factor AP-1. By retaining the phosphatase complex PP2A into the cytoplasm, prevents the dephosphorylation of the AP-1 subunit JUN which is required for proper activation of the transcription factor . Both inhibits and activates the TLR2-dependent signaling pathway . Positively regulates the TLR2 signaling pathway to activate specifically the downstream p38 and JNK MAP kinases and promote the polarization of macrophages toward the pro-inflammatory M1 phenotype . It may also play a role in the regulation of inflammation induced by high glucose through the PKB/AKT signaling pathway . Also involved in erythrocyte differentiation through activation of the ERK1/ERK2 signaling pathway . ECO:0000269|PubMed:24286120, ECO:0000269|PubMed:26599367, ECO:0000269|PubMed:28471450, ECO:0000269|PubMed:28609714,

Synonyms:  MFHAS1,  MFHAS1p,  hMFHAS1,  Q9Y4C4,  Q9Y4C4p ...

Linkouts:  STRING  Pharos  UniProt  OMIM

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence