ZNF431 localizations
ZNF431 [ENSP00000308578]
Zinc finger protein 431; Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1 (By similarity). ; Belongs to the krueppel C2H2-type zinc-finger protein family.
Synonyms: ZNF431, ZNF431p, hZNF431, A0A024R7Q8, M0QXY3 ...