SCUBE2 localizations
SCUBE2 [ENSP00000310658]
Signal peptide, CUB and EGF-like domain-containing protein 2; Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane . Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface . Synergizes with DISP1 to increase SHH secretion . Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis . ECO:0000269|PubMed:22902404, ECO:0000269|PubMed:24522195,
Synonyms: SCUBE2, SCUBE2p, hSCUBE2, A0A0A0MTC8, A0A3B3ISZ7 ...