COMPARTMENTS

Subcellular localization database

SCUBE2 localizations

SCUBE2 [ENSP00000310658]

Signal peptide, CUB and EGF-like domain-containing protein 2; Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane . Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface . Synergizes with DISP1 to increase SHH secretion . Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis . ECO:0000269|PubMed:22902404, ECO:0000269|PubMed:24522195,

Synonyms:  SCUBE2,  SCUBE2p,  hSCUBE2,  A0A0A0MTC8,  A0A3B3ISZ7 ...

Linkouts:  STRING  Pharos  UniProt

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence