COMPARTMENTS

Subcellular localization database

DIS3L2 localizations

DIS3L2 [ENSP00000315569]

DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. Rule:MF_03045, ECO:0000269|PubMed:23756462,; Belongs to the RNR ribonuclease family. DIS3L2 subfamily.

Synonyms:  DIS3L2,  DIS3L2p,  hDIS3L2,  C9JGP4,  H7C036 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence