CEP295 localizations
CEP295 [ENSP00000316681]
Centrosomal protein of 295 kDa; Centriole-enriched microtubule-binding protein involved in centriole biogenesis (PubMed:20844083, PubMed:25131205, PubMed:27185865). Essential for the generation of the distal portion of new-born centrioles in a CENPJ- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure . Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles . Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement . Binds to and stabilizes centriolar microtubule .
Synonyms: CEP295, CEP295p, hCEP295, E9PJG3, E9PJY3 ...