ARHGEF4 localizations
ARHGEF4 [ENSP00000316845]
Rho guanine nucleotide exchange factor 4; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up- regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. ECO:0000269|PubMed:12598901, ECO:0000269|PubMed:17145773,
Synonyms: ARHGEF4, ARHGEF4p, hARHGEF4, A0A087X0P1, A0A0C4DFY6 ...