COMPARTMENTS

Subcellular localization database

PCK1 localizations

PCK1 [ENSP00000319814]

Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate. ECO:0000269|PubMed:26971250, ECO:0000269|PubMed:28216384,; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Synonyms:  PCK1,  PCK1p,  hPCK1,  P35558,  P35558p ...

Linkouts:  STRING  Pharos  UniProt  OMIM

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence