RNF185 localizations
RNF185 [ENSP00000320508]
E3 ubiquitin-protein ligase RNF185; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 . Acts in the endoplasmic reticulum (ER)- associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation . Protects cells from ER stress-induced apoptosis . Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway . Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 .
Synonyms: RNF185, RNF185p, hRNF185, A0A024R1F5, A0A024R1H4 ...