PNKP localizations
PNKP [ENSP00000323511]
Bifunctional polynucleotide phosphatase/kinase; Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.
Synonyms: PNKP, A0A0D9SEV0, A0A0D9SFD6, A0A0D9SFL2, A0A0D9SFU1 ...