SPDYA localizations
SPDYA [ENSP00000335628]
Speedy protein A; Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 . Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate- binding cleft prior to kinase activation . Mediates cell survival during the DNA damage process through activation of CDK2 . ECO:0000269|PubMed:12839962, ECO:0000269|PubMed:12972555,; Belongs to the Speedy/Ringo family.
Synonyms: SPDYA, A0A384MTT5, E7EPV1, H7C0J1, Q5MJ70 ...