PACRG localizations
PACRG [ENSP00000337946]
Parkin coregulated gene protein; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.
Synonyms: PACRG, A0A087WT60, A0A087WXG4, H0YFE8, H0YFW3 ...