COMPARTMENTS

Subcellular localization database

SPTY2D1 localizations

SPTY2D1 [ENSP00000337991]

Protein SPT2 homolog; Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin . Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription . Binds DNA and histones and promotes nucleosome assembly (in vitro) (PubMed:23378026, PubMed:26109053). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 . Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA ; Belongs to the SPT2 family.

Synonyms:  SPTY2D1,  SPTY2D1p,  hSPTY2D1,  Q68D10,  Q68D10p ...

Linkouts:  STRING  Pharos  UniProt

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence