COMPARTMENTS

Subcellular localization database

KIR2DL4 localizations

KIR2DL4 [ENSP00000339634]

Killer cell immunoglobulin-like receptor 2DL4; Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy . May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells . Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent proinflammatory response . ECO:0000269|PubMed:16366734, ECO:0000269|PubMed:20179272,; Belongs to the immunoglobulin superfamily.

Synonyms:  KIR2DL4,  KIR2DL4p,  hKIR2DL4,  A0A0B4J1S6,  A0A376A8K3 ...

Linkouts:  STRING  Pharos  UniProt

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence