COMPARTMENTS

Subcellular localization database

ACER2 localizations

ACER2 [ENSP00000342609]

Alkaline ceramidase 2; Golgi ceramidase that catalyzes the hydrolysis of ceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:16940153, PubMed:18945876, PubMed:20207939, PubMed:20089856). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation . Has a better catalytic efficiency towards unsaturated long-chain ceramides, including C18:1-, C20:1- and C24:1-ceramides . Saturated long-chain ceramides and unsaturated very long-chain ceramides are also good substrates, whereas saturated very long-chain ceramides and short-chain ceramides are poor substrates . Also hydrolyzes dihydroceramides to produce dihydrosphingosine . It is the ceramidase that controls the levels of circulating sphingosine-1- phosphate and dihydrosphingosine-1-phosphate in plasma through their production by hematopoietic cells (By similarity). Regulates cell proliferation, autophagy and apoptosis by the production of sphingosine and sphingosine-1-phosphate (PubMed:16940153, PubMed:26943039, PubMed:28294157, PubMed:29229990). As part of a p53/TP53-dependent pathway, promotes for instance autophagy and apoptosis in response to DNA damage . Through the production of sphingosine, may also regulate the function of the Golgi complex and regulate the glycosylation of proteins . ECO:0000269|PubMed:16940153, ECO:0000269|PubMed:18945876, ECO:0000269|PubMed:20089856, ECO:0000269|PubMed:20207939, ECO:0000269|PubMed:20628055, ECO:0000269|PubMed:26943039, ECO:0000269|PubMed:28294157, ECO:0000269|PubMed:29229990,

Synonyms:  ACER2,  ACER2p,  hACER2,  Q5QJU3,  Q5QJU3p ...

Linkouts:  STRING  Pharos  UniProt  OMIM

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence