COMPARTMENTS

Subcellular localization database

NAA80 localizations

NAA80 [ENSP00000346927]

N-alpha-acetyltransferase 80; N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively) (PubMed:30028079, PubMed:29581253). N-terminal acetylation of processed beta- and gamma- actin regulates actin filament depolymerization and elongation . In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu . In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp . May act as a tumor suppressor . ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29581307,

Synonyms:  NAA80,  NAA80p,  hNAA80,  A0A1D5RMQ1,  C9J451 ...

Linkouts:  STRING  Pharos  UniProt

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence