COMPARTMENTS

Subcellular localization database

SLC17A5 localizations

SLC17A5 [ENSP00000348019]

Sialin; Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential-dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva. ECO:0000269|PubMed:11751519, ECO:0000269|PubMed:15510212,; Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.

Synonyms:  SLC17A5,  SLC17A5p,  hSLC17A5,  Q9NRA2,  Q9NRA2p ...

Linkouts:  STRING  Pharos  UniProt  OMIM

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence