ARPIN localizations
ARPIN [ENSP00000350075]
Arpin; Regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.
Synonyms: ARPIN, H0YL03, H0YMP5, Q7Z6K5, H0YL03p ...