C11orf80 localizations
C11orf80 [ENSP00000354227]
Type 2 DNA topoisomerase 6 subunit B-like; [Isoform 3]: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles.
Synonyms: C11orf80, A0A0A0MRH1, A0A140TA08, A0A2R8Y5A2, A0A2U3TZP7 ...