USP21 localizations
USP21 [ENSP00000356981]
Ubiquitin carboxyl-terminal hydrolase 21; Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates . Deubiquitinates BAZ2A/TIP5 leading to its stabilization .
Synonyms: USP21, USP21p, hUSP21, A0A1W2PQ32, A0A1W2PRX0 ...