AFG1L localizations
AFG1L [ENSP00000357973]
AFG1-like ATPase; Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain . Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress .
Synonyms: AFG1L, AFG1Lp, hAFG1L, A6ZJA2, H0Y5F4 ...