COMPARTMENTS

Subcellular localization database

MDN1 localizations

MDN1 [ENSP00000358400]

Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits . Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex . This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (By similarity); Belongs to the midasin family.

Synonyms:  MDN1,  MDN1p,  hMDN1,  M0QXR3,  Q5T795 ...

Linkouts:  STRING  Pharos  UniProt

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence