COMPARTMENTS

Subcellular localization database

SLF2 localizations

SLF2 [ENSP00000359292]

SMC5-SMC6 complex localization factor protein 2; Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance . The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks . Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions ; Belongs to the FAM178 family.

Synonyms:  SLF2,  SLF2p,  hSLF2,  A0A3B3IRS8,  B1AL16 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence