COMPARTMENTS

ZBP1 [ENSP00000360215]

Z-DNA-binding protein 1; Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).

Synonyms:  ZBP1,  ZBP1p,  hZBP1,  H0Y6D1,  Q9H171 ...

Linkouts:  STRING  Pharos  UniProt  OMIM