COMPARTMENTS

Subcellular localization database

SMPDL3B localizations

SMPDL3B [ENSP00000363001]

Acid sphingomyelinase-like phosphodiesterase 3b; Lipid-modulating phosphodiesterase . Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity). Has in vitro phosphodiesterase activity, but the physiological substrate is unknown . Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (By similarity). ; Belongs to the acid sphingomyelinase family.

Synonyms:  SMPDL3B,  SMPDL3Bp,  hSMPDL3B,  F8VWW8,  F8VXS3 ...

Linkouts:  STRING  Pharos  UniProt

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence