ASXL1 localizations
ASXL1 [ENSP00000364839]
Polycomb group protein ASXL1; Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG) . Acts as coactivator of RARA and RXRA through association with NCOA1 . Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non- catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) . Acts as a sensor of N(6)- methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing . ECO:0000269|PubMed:16606617, ECO:0000269|PubMed:20436459,
Synonyms: ASXL1, ASXL1p, hASXL1, A0A087WWN0, A0A2R8Y4U9 ...
Linkouts: STRING Pharos UniProt OMIM
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