PPP1R11 localizations
PPP1R11 [ENSP00000365963]
E3 ubiquitin-protein ligase PPP1R11; Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 . Inhibitor of protein phosphatase 1 .
Synonyms: PPP1R11, PPP1R11p, hPPP1R11, A2BEK1, O60927 ...