CD274 localizations
CD274 [ENSP00000370989]
Programmed cell death 1 ligand 1; Plays a critical role in induction and maintenance of immune tolerance to self . As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response . Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) .
Synonyms: CD274, CD274p, hCD274, Q9NZQ7, Q9NZQ7p ...