COMPARTMENTS

Subcellular localization database

TBC1D23 localizations

TBC1D23 [ENSP00000377700]

TBC1 domain family member 23; Putative Rab GTPase-activating protein which plays a role in vesicular trafficking . Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles . Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP- 1 . Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity). ECO:0000269|PubMed:28823707, ECO:0000269|PubMed:29084197,

Synonyms:  TBC1D23,  TBC1D23p,  hTBC1D23,  C9IZ32,  C9JAM5 ...

Linkouts:  STRING  Pharos  UniProt

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence