SLC28A1 localizations
SLC28A1 [ENSP00000378074]
Sodium/nucleoside cotransporter 1; Sodium-dependent and pyrimidine-selective transporter . Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). Transports uridine, cytidine, thymidine, and nucleoside-derived drugs . Transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
Synonyms: SLC28A1, SLC28A1p, hSLC28A1, B7Z3L6, O00337 ...