TTC3 localizations
TTC3 [ENSP00000381981]
E3 ubiquitin-protein ligase TTC3; E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains . Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus . Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation . Positively regulates TGFB1-induced epithelial- mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2 . Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK . Inhibits cell proliferation . ECO:0000269|PubMed:24695496, ECO:0000269|PubMed:30203323,
Synonyms: TTC3, TTC3p, hTTC3, A8MT23, B4DSZ9 ...