ATG4B localizations
ATG4B [ENSP00000384259]
Cysteine protease ATG4B; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. ECO:0000269|PubMed:17347651, ECO:0000269|PubMed:19322194,
Synonyms: ATG4B, ATG4Bp, hATG4B, C9J1C1, C9JIK8 ...