CTNNA2 localizations
CTNNA2 [ENSP00000384638]
Catenin alpha-2; May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth . It acts as negative regulator of Arp2/3 complex activity and Arp2/3- mediated actin polymerization . It thereby suppresses excessive actin branching which would impair neurite growth and stability . Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity).
Synonyms: CTNNA2, CTNNA2p, hCTNNA2, A0A0A0MRI5, A0A0A0MTJ6 ...