COMMD5 localizations
COMMD5 [ENSP00000394331]
COMM domain-containing protein 5; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes . Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B .
Synonyms: COMMD5, COMMD5p, hCOMMD5, E9PJE4, H0YEQ6 ...