SIGIRR localizations
SIGIRR [ENSP00000403104]
Single Ig IL-1-related receptor; Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor- proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Synonyms: SIGIRR, C9JFX4, E9PK23, E9PLG6, E9PSD9 ...