COMPARTMENTS

Subcellular localization database

RMND5B localizations

RMND5B [ENSP00000420875]

E3 ubiquitin-protein transferase RMND5B; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex . Catalytic activity of the complex is required for normal cell proliferation . The CTLH E3 ubiquitin- protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 .

Synonyms:  RMND5B,  RMND5Bp,  hRMND5B,  D6R9A2,  D6RER3 ...

Linkouts:  STRING  Pharos  UniProt

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence