SH3RF2 localizations
SH3RF2 [ENSP00000424497]
E3 ubiquitin-protein ligase SH3RF2; Has E3 ubiquitin-protein ligase activity . Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation . Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation . Inhibits PPP1CA phosphatase activity . ECO:0000269|PubMed:19945436, ECO:0000269|PubMed:22128169,
Synonyms: SH3RF2, SH3RF2p, hSH3RF2, Q8TEC5, Q8TEC5p ...