AMOTL2 localizations
AMOTL2 [ENSP00000424765]
Angiomotin-like protein 2; Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC; Belongs to the angiomotin family.
Synonyms: AMOTL2, AMOTL2p, hAMOTL2, D6RBK2, D6RCL7 ...