AMER2 localizations
AMER2 [ENSP00000426528]
APC membrane recruitment protein 2; Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex; Belongs to the Amer family.
Synonyms: AMER2, AMER2p, hAMER2, Q8N7J2, Q8N7J2p ...