SH2B2 localizations
SH2B2 [ENSP00000440273]
SH2B adapter protein 2; Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. ECO:0000269|PubMed:12400014, ECO:0000269|PubMed:15378031,
Synonyms: SH2B2, SH2B2p, hSH2B2, A0A087X016, C9JK89 ...