RNF213 localizations
RNF213 [ENSP00000464087]
E3 ubiquitin-protein ligase RNF213; E3 ubiquitin-protein ligase involved in angiogenesis . Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression . Also has ATPase activity (PubMed:24658080, PubMed:26126547). ECO:0000269|PubMed:24658080, ECO:0000269|PubMed:26126547,
Synonyms: RNF213, RNF213p, hRNF213, A0A0A0MTC1, A0A0A0MTR7 ...