TRABD2B localizations
TRABD2B [ENSP00000476820]
Metalloprotease TIKI2; Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation; Belongs to the TIKI family.
Synonyms: TRABD2B, TRABD2Bp, hTRABD2B, A6NFA1, A6NFA1p ...