DENND1B localizations
DENND1B [ENSP00000479816]
DENN domain-containing protein 1B; Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells . Acts by promoting the exchange of GDP to GTP, converting inactive GDP- bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis . Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity . Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells . ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:24520163,
Synonyms: DENND1B, DENND1Bp, hDENND1B, B3KR95, B7ZBL5 ...