COMPARTMENTS

Subcellular localization database

TADA2A localizations

TADA2A [ENSP00000481091]

Transcriptional adapter 2-alpha; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity . May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage .

Synonyms:  TADA2A,  TADA2Ap,  hTADA2A,  A0A024R0Y4,  A0A087WTV5 ...

Linkouts:  STRING  Pharos  UniProt

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence