PTGES3 localizations
PTGES3 [ENSP00000482075]
Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) . Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway . ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:12077419,
Synonyms: PTGES3, PTGES3p, hPTGES3, A0A024RB32, A0A087WYT3 ...