N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta; Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components; Astacins
Synonyms: MEP1B, MEP1Bp, hMEP1B, J3KRK1, J3QKX5 ...