COMPARTMENTS

DUSP6 [ENSP00000279488]

Dual specificity protein phosphatase 6; Inactivates MAP kinases. Has a specificity for the ERK family . Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors . ; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.

Synonyms:  DUSP6,  DUSP6p,  hDUSP6,  A0A024RBC1,  F8VW29 ...

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